Expression of underglycosylated MUC1 antigen in cancerous and adjacent normal breast tissues.

ABSTRACT:

Introduction

Mucin 1 antigen (MUC1) is a high-molecular-weight transmembrane glycoprotein with an aberrant expression profile in various malignancies, including breast cancer. Its increased overexpression and underglycosylation in breast cancer is associated with tumor invasiveness and metastatic potential. In this study, we took the next step toward establishing MUC1 as a potential diagnostic, prognostic, and therapeutic target by investigating its expression and posttranslational modification (glycosylation/sialylation).

Patients and methods

In these studies we used a breast cancer tissue microarray (TMA) and fresh-frozen multistage breast cancer tissues. We analyzed in detail the expression of normal and underglycosylated/sialated MUC1 by immunohistochemical techniques, r

SUBMITTER: Ghosh SK 

PROVIDER: S-EPMC3578066 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature