Structural brain alterations can be detected early in HIV infection.

ABSTRACT:

Objective

Brain changes occurring early in HIV infection are not well characterized. The Chicago Early HIV Infection Study aimed to evaluate the presence and extent of structural brain alterations using quantitative MRI.

Methods

Forty-three HIV and 21 control subjects were enrolled. Mean length of infection was estimated as less than 1 year based on assay results. High-resolution neuroanatomical images were acquired. Automated image analysis was used to derive measurements for total brain, ventricular volume, and for tissue classes (total and cortical gray matter, white matter, and CSF). A separate image analysis algorithm was used to calculate measurements for individual brain regions. Cognitive function was assessed by neuropsychological evaluation.

Results

Reductio

SUBMITTER: Ragin AB 

PROVIDER: S-EPMC3578377 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature