Hippocampal perfusion predicts impending neurodegeneration in REM sleep behavior disorder.

ABSTRACT:

Objectives

Patients with idiopathic REM sleep behavior disorder (IRBD) are at risk for developing Parkinson disease (PD) and dementia with Lewy bodies (DLB). We aimed to identify functional brain imaging patterns predicting the emergence of PD and DLB in patients with IRBD, using SPECT with (99m)Tc-ethylene cysteinate dimer (ECD).

Methods

Twenty patients with IRBD were scanned at baseline during wakefulness using (99m)Tc-ECD SPECT. After a follow-up of 3 years on average, patients were divided into 2 groups according to whether or not they developed defined neurodegenerative disease (PD, DLB). SPECT data analysis comparing regional cerebral blood flow (rCBF) between groups assessed whether specific brain perfusion patterns were associated with subsequent clinical evolution.

SUBMITTER: Dang-Vu TT 

PROVIDER: S-EPMC3578380 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature