Association of vitamin D deficiency with incidence of type 2 diabetes in high-risk Asian subjects.

ABSTRACT:

Background

Recent studies suggest an association between 25-hydroxyvitamin D [25(OH)D] and type 2 diabetes (T2D) risk. However, prospective studies investigating the relation between vitamin D inadequacy and incidence of T2D incorporating obesity and dynamic measures of insulin resistance (IR) and pancreatic β cell function are limited.

Objective

We tested the hypothesis that baseline 25(OH)D is associated with the incidence of T2D in high-risk subjects for up to 5 y of follow-up, independently of obesity, baseline IR, and β cell function.

Design

We recruited 1080 nondiabetic Korean subjects [mean ± SD age: 49.5 ± 11.4 y] based on the presence of one or more risk factors for T2D, including obesity, hypertension, dyslipidemia, and/or family history of T2D. We measured

SUBMITTER: Lim S 

PROVIDER: S-EPMC3578401 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature