PcG-mediated higher-order chromatin structures modulate replication programs at the Drosophila BX-C.

ABSTRACT: Polycomb group proteins (PcG) exert conserved epigenetic functions that convey maintenance of repressed transcriptional states, via post-translational histone modifications and high order structure formation. During S-phase, in order to preserve cell identity, in addition to DNA information, PcG-chromatin-mediated epigenetic signatures need to be duplicated requiring a tight coordination between PcG proteins and replication programs. However, the interconnection between replication timing control and PcG functions remains unknown. Using Drosophila embryonic cell lines, we find that, while presence of specific PcG complexes and underlying transcription state are not the sole determinants of cellular replication timing, PcG-mediated higher-order structures appear to dictate the timing of rep

SUBMITTER: Lo Sardo F 

PROVIDER: S-EPMC3578750 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature