From hub proteins to hub modules: the relationship between essentiality and centrality in the yeast interactome at different scales of organization.

ABSTRACT: Numerous studies have suggested that hub proteins in the S. cerevisiae physical interaction network are more likely to be essential than other proteins. The proposed reasons underlying this observed relationship between topology and functioning have been subject to some controversy, with recent work suggesting that it arises due to the participation of hub proteins in essential complexes and processes. However, do these essential modules themselves have distinct network characteristics, and how do their essential proteins differ in their topological properties from their non-essential proteins? We aimed to advance our understanding of protein essentiality by analyzing proteins, complexes and processes within their broader functional context and by considering physical interactions both wit

SUBMITTER: Song J 

PROVIDER: S-EPMC3578755 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature