Lessons from Dwarf8 on the strengths and weaknesses of structured association mapping.

ABSTRACT: The strengths of association mapping lie in its resolution and allelic richness, but spurious associations arising from historical relationships and selection patterns need to be accounted for in statistical analyses. Here we reanalyze one of the first generation structured association mapping studies of the Dwarf8 (d8) locus with flowering time in maize using the full range of new mapping populations, statistical approaches, and haplotype maps. Because this trait was highly correlated with population structure, we found that basic structured association methods overestimate phenotypic effects in the region, while mixed model approaches perform substantially better. Combined with analysis of the maize nested association mapping population (a multi-family crossing design), it is concluded t

SUBMITTER: Larsson SJ 

PROVIDER: S-EPMC3578782 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature