Safety of benzathine penicillin for preventing congenital syphilis: a systematic review.

ABSTRACT:

Objective

To estimate the risk of serious adverse reactions to benzathine penicillin in pregnant women for preventing congenital syphilis.

Methods

We searched for clinical trials or cohorts that assessed the incidence of serious adverse reactions to benzathine penicillin in pregnant women and the general population (indirect evidence). MEDLINE, EMBASE, Scopus and other databases were searched up to December 2012. The GRADE approach was used to assess quality of evidence. Absolute risks of each study were calculated along with their 95% confidence intervals (95% CI). We employed the DerSimonian and Laird random effects model in the meta-analyses.

Results

From 2,765 retrieved studies we included 13, representing 3,466,780 patients. The studies that included pregnant wom

SUBMITTER: Galvao TF 

PROVIDER: S-EPMC3578834 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature