Global analysis of the human pathophenotypic similarity gene network merges disease module components.

ABSTRACT: The molecular complexity of genetic diseases requires novel approaches to break it down into coherent biological modules. For this purpose, many disease network models have been created and analyzed. We highlight two of them, "the human diseases networks" (HDN) and "the orphan disease networks" (ODN). However, in these models, each single node represents one disease or an ambiguous group of diseases. In these cases, the notion of diseases as unique entities reduces the usefulness of network-based methods. We hypothesize that using the clinical features (pathophenotypes) to define pathophenotypic connections between disease-causing genes improve our understanding of the molecular events originated by genetic disturbances. For this, we have built a pathophenotypic similarity gene network (PS

SUBMITTER: Reyes-Palomares A 

PROVIDER: S-EPMC3578923 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature