Dataset Information

Obesity in children with poorly controlled asthma: Sex differences.

ABSTRACT:

Background

Obesity increases asthma risk, and may alter asthma severity. In adults, sex appears to modify the effect of obesity on asthma. Among children, the effect of sex on the relationship between obesity and asthma severity remains less clear, particularly when considering race.

Objective

To determine how obesity affects disease characteristics in a diverse cohort of children with poorly controlled asthma, and if obesity effects are altered by sex.

Design

We analyzed 306 children between 6 and 17 years of age with poorly controlled asthma enrolled in a 6-month trial assessing lansoprazole for asthma control. In this secondary analysis, we determined associations between obesity and symptom severity, spirometry, exacerbation risk, airway biomarkers, bronchial reactivity, and airflow perception. We used both a multivariate linear regression and longitudinal mixed-effect model to determine if obesity interacted with sex to affect asthma severity.

Results

Regardless of sex, BMI >95th percentile did not affect asthma control, exacerbation risk or airway biomarkers. Sex changed the effect of obesity on lung function (sex × obesity FEV1%, interaction P-value < 0.01, sex × obesity FEV1/FVC, interaction P-value = 0.03). Obese males had significantly worse airflow obstruction compared to non-obese males, while in females there was no obesity effect on airflow obstruction. In females, obesity was associated with significantly greater FEV1 and FVC, and a trend toward reduced airway reactivity.

Conclusions

Obesity did not affect asthma control, airway markers or disease stability; however obesity did affect lung function in a sex-dependent manner. In males, obesity associated with reduced FEV1/FVC, and in females, obesity associated with substantially improved lung function.

SUBMITTER: Lang JE

PROVIDER: S-EPMC3578966 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Obesity in children with poorly controlled asthma: Sex differences.

Lang Jason E JE Holbrook Janet T JT Wise Robert A RA Dixon Anne E AE Teague W Gerald WG Wei Christine Y CY Irvin Charles G CG Shade David D Lima John J JJ

Pediatric pulmonology 20121109 9

<h4>Background</h4>Obesity increases asthma risk, and may alter asthma severity. In adults, sex appears to modify the effect of obesity on asthma. Among children, the effect of sex on the relationship between obesity and asthma severity remains less clear, particularly when considering race.<h4>Objective</h4>To determine how obesity affects disease characteristics in a diverse cohort of children with poorly controlled asthma, and if obesity effects are altered by sex.<h4>Design</h4>We analyzed 3 ...[more]

PMID: 23143849

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Dataset Information

Obesity in children with poorly controlled asthma: Sex differences.

Background

Objective

Design

Results

Conclusions

Publications

Obesity in children with poorly controlled asthma: Sex differences.

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