Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials.

ABSTRACT:

Background and purpose

Understanding drug effects on the heart is key to safety pharmacology assessment and anti-arrhythmic therapy development. Here our goal is to demonstrate the ability of computational models to simulate the effect of drug action on the electrical activity of the heart, at the level of the ion-channel, cell, heart and ECG body surface potential.

Experimental approach

We use the state-of-the-art mathematical models governing the electrical activity of the heart. A drug model is introduced using an ion channel conductance block for the hERG and fast sodium channels, depending on the IC(50) value and the drug dose. We simulate the ECG measurements at the body surface and compare biomarkers under different drug actions.

Key results

Introducing a 50%

SUBMITTER: Zemzemi N 

PROVIDER: S-EPMC3579290 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature