Thioredoxin and thioredoxin target proteins: from molecular mechanisms to functional significance.

ABSTRACT: The thioredoxin (Trx) system is one of the central antioxidant systems in mammalian cells, maintaining a reducing environment by catalyzing electron flux from nicotinamide adenine dinucleotide phosphate through Trx reductase to Trx, which reduces its target proteins using highly conserved thiol groups. While the importance of protecting cells from the detrimental effects of reactive oxygen species is clear, decades of research in this field revealed that there is a network of redox-sensitive proteins forming redox-dependent signaling pathways that are crucial for fundamental cellular processes, including metabolism, proliferation, differentiation, migration, and apoptosis. Trx participates in signaling pathways interacting with different proteins to control their dynamic regulation of stru

SUBMITTER: Lee S 

PROVIDER: S-EPMC3579385 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature