Novel polymorphisms associated with tacrolimus trough concentrations: results from a multicenter kidney transplant consortium.

ABSTRACT:

Background

The CYP4503A5*1 genotype is associated with lower tacrolimus concentrations. Although its effect is important, it incompletely explains the variability in tacrolimus concentrations and has a relatively low minor allele frequency in whites relative to African Americans (AA).

Methods

We studied clinical and recipient genetic correlates of dose-normalized tacrolimus troughs (n=12,277) in the first 6 months posttransplant using a customized single-nucleotide polymorphism chip with 2722 variants in a large, ethnically diverse (144 AA and 551 non-AA) adult kidney transplant population through a seven-center consortium.

Results

During the 6-month study, AAs had consistently lower median (interquartile range) troughs than non-AAs, 6.2 (4.4-8.4) ng/mL vs. 8.3 (6.4-1

SUBMITTER: Jacobson PA 

PROVIDER: S-EPMC3579501 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature