Vitamin and antioxidant rich diet increases MLH1 promoter DNA methylation in DMT2 subjects.

ABSTRACT:

Unlabelled

Background

Oxidative stress may lead to an increased level of unrepaired cellular DNA damage, which is discussed as one risk for tumor initiation. Mismatch repair (MMR) enzymes act as proofreading complexes that maintain the genomic integrity and MMR-deficient cells show an increased mutation rate. One important gene in the MMR complex is the MutL homolog 1 (MLH1) gene. Since a diet rich in antioxidants has the potential to counteract harmful effects by reactive oxygen species (ROS), we investigated the impact of an antioxidant, folate, and vitamin rich diet on the epigenetic pattern of MLH1. These effects were analyzed in individuals with non-insulin depended diabetes mellitus type 2 (NIDDM2) and impaired fasting glucose (IFG).

Methods

In this post-hoc an

SUBMITTER: Switzeny OJ 

PROVIDER: S-EPMC3579724 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature