Molecular analyses of Fusarium isolates recovered from a cluster of invasive mold infections in a Brazilian hospital.

ABSTRACT:

Background

Invasive fusariosis (IF) is a rare but often fatal fungal infection in immunosuppressed patients. In 2007, cases of IF above the expected epidemiologic baseline were detected in the hematology ward of a hospital in Rio de Janeiro, Brazil. Possible sources of infection were investigated by performing environmental sampling and patient isolate collection, followed by molecular typing. Isolates from dermatology patients with superficial fusariosis were included in the study for comparison to molecular types found in the community.

Methods

Environmental sampling focused on water-related sources in and around the hematology ward. Initially, we characterized 166 clinical and environmental isolates using the Fusarium translation elongation factor 1α (EF-1α) genetic locus

SUBMITTER: Scheel CM 

PROVIDER: S-EPMC3579725 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature