Global and stage specific patterns of Kruppel-associated-box zinc finger protein gene expression in murine early embryonic cells.

ABSTRACT: Highly coordinated transcription networks orchestrate the self-renewal of pluripotent stem cell and the earliest steps of mammalian development. KRAB-containing zinc finger proteins represent the largest group of transcription factors encoded by the genomes of higher vertebrates including mice and humans. Together with their putatively universal cofactor KAP1, they have been implicated in events as diverse as the silencing of endogenous retroelements, the maintenance of imprinting and the pluripotent self-renewal of embryonic stem cells, although the genomic targets and specific functions of individual members of this gene family remain largely undefined. Here, we first generated a list of Ensembl-annotated KRAB-containing genes encoding the mouse and human genomes. We then defined the tra

SUBMITTER: Corsinotti A 

PROVIDER: S-EPMC3579818 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature