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ABSTRACT: Background
Research using electronic health records (EHRs) relies heavily on coded clinical data. Due to variation in coding practices, it can be difficult to aggregate the codes for a condition in order to define cases. This paper describes a methodology to develop 'indicator markers' found in patients with early rheumatoid arthritis (RA); these are a broader range of codes which may allow a probabilistic case definition to use in cases where no diagnostic code is yet recorded.Methods
We examined EHRs of 5,843 patients in the General Practice Research Database, aged ≥ 30 y, with a first coded diagnosis of RA between 2005 and 2008. Lists of indicator markers for RA were developed initially by panels of clinicians drawing up code-lists and then modified based on scrutiny of
SUBMITTER: Nicholson A
PROVIDER: S-EPMC3579840 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature