Low SGK1 expression in human adrenocortical tumors is associated with ACTH-independent glucocorticoid secretion and poor prognosis.

ABSTRACT:

Context

Using single-nucleotide polymorphism analysis, we observed allelic loss of the gene for serum glucocorticoid (GC) kinase 1 (SGK1), a GC-responsive kinase involved in multiple cellular functions, in a subset of cortisol-secreting adenomas.

Objective

Our objective was to analyze SGK1 expression in adrenocortical tumors and to further characterize its role in ACTH-independent cortisol secretion, tumor progression, and prognosis.

Design and setting

Gene expression levels of SGK1, SGK3, and CTNNB1 (coding for β-catenin) and protein expression levels of SGK1, nuclear β-catenin, and phosphorylated AKT were determined in adrenocortical tumors and normal adrenal glands.

Patients

A total of 227 adrenocortical tumors (40 adenomas and 187 carcinomas) and 25 normal

SUBMITTER: Ronchi CL 

PROVIDER: S-EPMC3579951 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature