Chromosome damage in human cells by γ rays, α particles and heavy ions: track interactions in basic dose-response relationships.

ABSTRACT: We irradiated normal human lymphocytes and fibroblasts with (137)Cs γ rays, 3.5 MeV α particles and 1 GeV/amu (56)Fe ions and measured the subsequent formation of chromosome-type aberrations by mFISH at the first mitosis following irradiation. This was done for the purposes of characterizing the shape of dose-response relationships and determining the frequency distribution of various aberration types with respect to the parameters of dose, radiation quality and cell type. Salient results and conclusions include the following. For low-LET γ rays, lymphocytes showed a more robust dose response for overall damage and a higher degree of upward curvature compared to fibroblasts. For both sources of high-LET radiation, and for both cell types, the response for simple and complex exchanges was l

SUBMITTER: Loucas BD 

PROVIDER: S-EPMC3580060 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature