Gene expression signatures of radiation exposure in peripheral white blood cells of smokers and non-smokers.

ABSTRACT:

Purpose

The issue of potential confounding factors is critical to the development of any approach to radiation biodosimetry, and has not been fully addressed for gene expression-based approaches.

Materials and methods

As a step in this direction, we have investigated the effect of smoking on the global radiation gene expression response in ex vivo-irradiated peripheral blood cells using microarray analysis. We also evaluated the ability of gene expression signatures to predict the radiation exposure level of ex vivo-exposed samples from smokers and non-smokers of both genders.

Results

We identified eight genes with a radiation response that was significantly affected by smoking status, and confirmed an effect of smoking on the radiation response of the four and a half

SUBMITTER: Paul S 

PROVIDER: S-EPMC3580190 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature