Exploring the interaction between SNP genotype and postmenopausal hormone therapy effects on stroke risk.

ABSTRACT:

Background

Genome-wide association studies have identified several genomic regions that are associated with stroke risk, but these provide an explanation for only a small fraction of familial stroke aggregation. Genotype by environment interactions may contribute further to such an explanation. The Women's Health Initiative (WHI) clinical trial found increased stroke risk with postmenopausal hormone therapy (HT) and provides an efficient setting for evaluating genotype-HT interaction on stroke risk.

Methods

We examined HT by genotype interactions for 392 SNPs selected from candidate gene studies, and 2,371 SNPs associated with changes in blood protein concentrations after hormone therapy, in analyses that included 2,045 postmenopausal women who developed stroke during WHI cl

SUBMITTER: Huang Y 

PROVIDER: S-EPMC3580413 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature