Metformin overdose, but not lactic acidosis per se, inhibits oxygen consumption in pigs.

ABSTRACT:

Introduction

Hepatic mitochondrial dysfunction may play a critical role in the pathogenesis of metformin-induced lactic acidosis. However, patients with severe metformin intoxication may have a 30 to 60% decrease in their global oxygen consumption, as for generalized inhibition of mitochondrial respiration. We developed a pig model of severe metformin intoxication to validate this clinical finding and assess mitochondrial function in liver and other tissues.

Methods

Twenty healthy pigs were sedated and mechanically ventilated. Ten were infused with a large dose of metformin (4 to 8 g) and five were not (sham controls). Five others were infused with lactic acid to clarify whether lactic acidosis per se diminishes global oxygen use. Arterial pH, lactatemia, global oxygen consu

SUBMITTER: Protti A 

PROVIDER: S-EPMC3580617 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature