A distinct influenza infection signature in the blood transcriptome of patients with severe community-acquired pneumonia.

ABSTRACT:

Introduction

Diagnosis of severe influenza pneumonia remains challenging because of a lack of correlation between the presence of influenza virus and clinical status. We conducted gene-expression profiling in the whole blood of critically ill patients to identify a gene signature that would allow clinicians to distinguish influenza infection from other causes of severe respiratory failure, such as bacterial pneumonia, and noninfective systemic inflammatory response syndrome.

Methods

Whole-blood samples were collected from critically ill individuals and assayed on Illumina HT-12 gene-expression beadarrays. Differentially expressed genes were determined by linear mixed-model analysis and overrepresented biological pathways determined by using GeneGo MetaCore.

Results

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SUBMITTER: Parnell GP 

PROVIDER: S-EPMC3580747 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature