APOE ε4 increases risk for dementia in pure synucleinopathies.

ABSTRACT:

Objective

To test for an association between the apolipoprotein E (APOE) ϵ4 allele and dementias with synucleinopathy.

Design

Genetic case-control association study.

Setting

Academic research.

Patients

Autopsied subjects were classified into 5 categories: dementia with high-level Alzheimer disease (AD) neuropathologic changes (NCs) but without Lewy body disease (LBD) NCs (AD group; n=244), dementia with LBDNCs and high-level ADNCs (LBD-AD group; n=224), dementia with LBDNCs and no or low levels of ADNCs (pure DLB [pDLB] group; n=91), Parkinson disease dementia (PDD) with no or low levels of ADNCs (n=81), and control group (n=269). MAIN OUTCOME MEASURE The APOE allele frequencies. RESULTS The APOE ϵ4 allele frequency was significantly higher in the AD (38.1%), L

SUBMITTER: Tsuang D 

PROVIDER: S-EPMC3580799 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature