Complement factor H Val62Ile variant and risk of age-related macular degeneration: a meta-analysis.

ABSTRACT:

Purpose

To evaluate the precise association of complement factor H (CFH) Val62Ile polymorphism with age-related macular degeneration (AMD) susceptibility.

Methods

We performed a meta-analysis using databases including PubMed, EMBASE, and Web of Science to find relevant studies. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using fixed-effect and random-effects models. The inconsistency index (I(2)) was used to assess heterogeneity. Funnel plots and Egger's test were used to evaluate publication bias. Sensitivity analysis was also performed.

Results

Fourteen studies including 4,438 patients with AMD and 6,099 controls based on the search criteria were involved in the meta-analysis. In overall populations, the pooled OR(1) for genotype GA+G

SUBMITTER: Yuan D 

PROVIDER: S-EPMC3580987 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature