Intramyocardial injection of platelet gel promotes endogenous repair and augments cardiac function in rats with myocardial infarction.

ABSTRACT:

Objectives

This study sought to explore the therapeutic potential of platelet gel for the treatment of myocardial infarction.

Background

Cardiac dysfunction after acute myocardial infarction is a major cause of heart failure. Current therapy relies on prompt reperfusion and blockage of secondary maladaptive pathways by small molecules. Platelet gels are biomaterials rich in cytokines and growth factors, which can be manufactured in an autologous manner and are effective in various models of wound healing. However, the potential utility of platelet gel in cardiac regeneration has yet to be tested.

Methods

Platelet gel was derived from syngeneic rats and its morphology, biocompatibility, secretion of beneficial factors, and in vivo degradation profile were characterized

SUBMITTER: Cheng K 

PROVIDER: S-EPMC3581074 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature