Ontology highlight
ABSTRACT:
SUBMITTER: Mucida D
PROVIDER: S-EPMC3581083 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Nature immunology 20130120 3
TCRαβ thymocytes differentiate into either CD8αβ(+) cytotoxic T lymphocytes or CD4(+) helper T cells. This functional dichotomy is controlled by key transcription factors, including the helper T cell master regulator ThPOK, which suppresses the cytolytic program in major histocompatibility complex (MHC) class II-restricted CD4(+) thymocytes. ThPOK continues to repress genes of the CD8 lineage in mature CD4(+) T cells, even as they differentiate into effector helper T cell subsets. Here we found ...[more]