Association of apolipoprotein A5 gene -1131T>C polymorphism with the risk of metabolic syndrome in Korean subjects.

ABSTRACT: We assessed the associations between the APOA5  -1131T>C polymorphism and lipid parameters and other risk factors of the metabolic syndrome in Korean subjects. A total of 2,901 participants from 20 oriental medical hospitals in Korea were enrolled between 2006 and 2011. According to the modified National Cholesterol Education Program Adult Treatment Panel III definitions, subjects were classified into the metabolic syndrome group and control group. The APOA5  -1131T>C genotype was significantly associated with serum high-density lipoprotein cholesterol levels (effect = - 1.700 mg/dL, P=6.550-E07) in the total study population after adjustment for differences in age and gender. The association of the APOA5  -1131T>C genotype with serum log-transformed triglyceride was also significant in an

SUBMITTER: Song KH 

PROVIDER: S-EPMC3581288 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature