Susceptibility to declarative memory interference is pronounced in primary insomnia.

ABSTRACT: Sleep has been shown to stabilize memory traces and to protect against competing interference in both the procedural and declarative memory domain. Here, we focused on an interference learning paradigm by testing patients with primary insomnia (N = 27) and healthy control subjects (N = 21). In two separate experimental nights with full polysomnography it was revealed that after morning interference procedural memory performance (using a finger tapping task) was not impaired in insomnia patients while declarative memory (word pair association) was decreased following interference. More specifically, we demonstrate robust associations of central sleep spindles (in N3) with motor memory susceptibility to interference as well as (cortically more widespread) fast spindle associations with decla

SUBMITTER: Griessenberger H 

PROVIDER: S-EPMC3581453 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature