The therapeutic role of monocyte chemoattractant protein-1 in a renal tissue engineering strategy for diabetic patients.

ABSTRACT: In this study we aim to boost the functional output of the intra-kidney islet transplantation for diabetic patients using a tissue engineered polymeric scaffold. This highly porous electrospun scaffold featured randomly distributed fibers composed of polycaprolactone (PCL) and poliglecaprone (PGC). It successfully sustained murine islets in vitro for up to 4 weeks without detected cytotoxicity. The in vivo study showed that the islet population proliferated by 89% within 12 weeks when they were delivered by the scaffold but only 18% if freely injected. Correspondingly, the islet population delivered by the scaffold unleashed a greater capability to produce insulin that in turn further drove down the blood glucose within 12 weeks after the surgery. Islets delivered by the scaffold most effe

SUBMITTER: Yin H 

PROVIDER: S-EPMC3581514 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature