Suppression of the macrophage proteasome by ethanol impairs MHC class I antigen processing and presentation.

ABSTRACT: Alcohol binge-drinking (acute ethanol consumption) is immunosuppressive and alters both the innate and adaptive arms of the immune system. Antigen presentation by macrophages (and other antigen presenting cells) represents an important function of the innate immune system that, in part, determines the outcome of the host immune response. Ethanol has been shown to suppress antigen presentation in antigen presenting cells though mechanisms of this impairment are not well understood. The constitutive and immunoproteasomes are important components of the cellular proteolytic machinery responsible for the initial steps critical to the generation of MHC Class I peptides for antigen presentation. In this study, we used an in-vitro cell culture model of acute alcohol exposure to study the effect o

SUBMITTER: D'Souza AJ 

PROVIDER: S-EPMC3581560 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature