Enhanced IL-17 signalling following myocardial ischaemia/reperfusion injury.

ABSTRACT:

Background

IL-17A and IL-17F are pro-inflammatory cytokines which induce the expression of several cytokines, chemokines and matrix metalloproteinases (MMPs) in target cells. IL-17 cytokines have recently attracted huge interest due to their pathogenic role in diseases such as arthritis and inflammatory bowel disease although a role for IL-17 cytokines in myocardial infarction (MI) has not previously been described.

Methods

In vivo MI was performed by coronary artery occlusion in the absence or presence of a neutralizing IL-17 antibody for blocking IL-17 actions in vivo. IL-17 signaling was also assessed in isolated primary cardiomyocytes by Western blot, mRNA expression and immunostaining.

Results

Expression of IL-17A, IL-17F and the IL-17 receptor (IL-17RA) were all

SUBMITTER: Barry SP 

PROVIDER: S-EPMC3581775 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature