Impact of uremia on human adipose tissue phenotype.

ABSTRACT:

Background

Recognition of adipose-related signaling in surgery is increasing, although direct interrogation of human adipose has been sparse. Few scenarios rival uremia for health impact. We hypothesized that adipose from uremic patients holds a relatively higher adipose-derived hormone and proinflammatory adipokine signature; we simultaneously evaluated the impact of clinical parameters on adipose phenotype.

Materials and methods

Adipose was harvested from surgical patients. Histology and protein analyses were completed for select mediators.

Results

In the overall cohort of 71 patients, the mean age was 63.4 y; 46.4% of patients had diabetes mellitus, 49.2% had hyperlipidemia, and 53.5% had coronary artery disease. Compared with nonuremic patients, uremic patients ha

SUBMITTER: Ho KJ 

PROVIDER: S-EPMC3581854 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature