Transcriptome analysis of Inbred Long Sleep and Inbred Short Sleep mice.

ABSTRACT: Many studies have utilized the Inbred Long Sleep and Inbred Short Sleep mouse strains to model the genetic influence on initial sensitivity to ethanol. The mechanisms underlying this divergent phenotype are still not completely understood. In this study, we attempt to identify genes that are differentially expressed between these two strains and to identify baseline networks of co-expressed genes, which may provide insight regarding their phenotypic differences. We examined the whole brain and striatal transcriptomes of both strains, using next generation RNA sequencing techniques. Many genes were differentially expressed between strains, including several in chromosomal regions previously shown to influence initial sensitivity to ethanol. These results are in concordance with a similar sa

SUBMITTER: Darlington TM 

PROVIDER: S-EPMC3581861 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature