Inflammation-initiating illnesses, inflammation-related proteins, and cognitive impairment in extremely preterm infants.

ABSTRACT: Neonatal inflammation is associated with perinatal brain damage. We evaluated to what extent elevated blood levels of inflammation-related proteins supplement information about the risk of impaired early cognitive function provided by inflammation-related illnesses. From 800 infants born before the 28th week of gestation, we collected blood spots on days 1, 7 and 14, for analysis of 25 inflammation-related proteins, and data about culture-positive bacteremia, necrotizing enterocolitis (Bell stage IIIb), and isolated perforation of the intestine, during the first two weeks, and whether they were ventilated on postnatal day 14. We considered a protein to be persistently or recurrently elevated if its concentration was in the top quartile (for gestational age and day blood was collected) on t

SUBMITTER: O'Shea TM 

PROVIDER: S-EPMC3582030 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature