Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Chinese Han population: a case-control study.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is influenced by both environmental and genetic factors. Few gene studies of the Chinese population have focused on COPD. We investigated candidate genes associated with susceptibility to COPD in the Chinese Han population.

Methods

A total of 331 COPD patients and 213 control subjects were recruited for this study. Nighty-seven single-nucleotide polymorphisms (SNPs) of 46 genes were selected for genotyping. Genotypes were determined using multiplex polymerase chain reaction (PCR).

Results

Significant differences between patients and healthy controls were observed in the allele frequencies of seven SNPs: rs1205 C, rs2353397 C, rs20541 T, rs2070600 G, rs10947233 G, rs1800629 G, and rs2241712 A. After Bonferroni cor

SUBMITTER: Guo Y 

PROVIDER: S-EPMC3582579 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature