Intravenous administration of achyranthes bidentata polypeptides supports recovery from experimental ischemic stroke in vivo.

ABSTRACT:

Background

Achyranthes bidentata Blume (A. bidentata) is a commonly prescribed Chinese medicinal herb. A. bidentata polypeptides (ABPP) is an active composite constituent, separated from the aqueous extract of A. bidentata. Our previous studies have found that ABPP have the neuroprotective function in vitro and in rat middle cerebral artery occlusion (MCAO) model in attenuating the brain infract area induced by focal ischemia-reperfusion. However, the ultimate goal of the stroke treatment is the restoration of behavioral function. Identifying behavioral deficits and therapeutic treatments in animal models of ischemic stroke is essential for potential translational applications.

Methodology and principal findings

The effect of ABPP on motor, sensory, and cognitive function in

SUBMITTER: Shen H 

PROVIDER: S-EPMC3582638 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature