Inflammatory T helper 17 cells promote depression-like behavior in mice.

ABSTRACT:

Background

Recognition of substantial immune-neural interactions is revising dogmas about their insular actions and revealing that immune-neural interactions can substantially impact central nervous system functions. The inflammatory cytokine interleukin-6 promotes susceptibility to depression and drives production of inflammatory T helper 17 (Th17) T cells, raising the hypothesis that in mouse models, Th17 cells promote susceptibility to depression-like behaviors.

Methods

Behavioral characteristics were measured in male mice administered Th17 cells, CD4(+) cells, or vehicle and in retinoid-related orphan receptor-γT (RORγT)(+/GFP) mice or male mice treated with RORγT inhibitor or anti-interleukin-17A antibodies.

Results

Mouse brain Th17 cells were elevated by learned

SUBMITTER: Beurel E 

PROVIDER: S-EPMC3582833 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature