Kit signaling is involved in melanocyte stem cell fate decisions in zebrafish embryos.

ABSTRACT: Adult stem cells are crucial for growth, homeostasis and repair of adult animals. The melanocyte stem cell (MSC) and melanocyte regeneration is an attractive model for studying regulation of adult stem cells. The process of melanocyte regeneration can be divided into establishment of the MSC, recruitment of the MSC to produce committed daughter cells, and the proliferation, differentiation and survival of these daughter cells. Reduction of Kit signaling results in dose-dependent reduction of melanocytes during larval regeneration. Here, we use clonal analysis techniques to develop assays to distinguish roles for these processes during zebrafish larval melanocyte regeneration. We use these clonal assays to investigate which processes are affected by the reduction in Kit signaling. We show t

SUBMITTER: O'Reilly-Pol T 

PROVIDER: S-EPMC3583038 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature