A comparison of E15.5 fetus and newborn rat serum proteomes.

ABSTRACT:

Unlabelled

Background

Serum proteins carry out several functions in the circulation, including transfer, immunological functions, messenger functions, coagulation, and regulation of homeostasis. To investigate changes in serum proteins that occur during development, the serum proteomes of embryonic 15.5 (E15.5) fetuses and newborn rats were compared using LC-MS/MS.

Results

A total of 958 proteins were identified in the serum of rats at both developmental stages. The serum proteome pattern of newborn rats was compared to E15.5 fetuses by relative quantitation. The expression patterns of hemoglobin subunits were different at the two stages, with most of the subunits having decreased expression in newborn rats compared to E15.5 fetuses. In addition, 8 of 12 apolipoprote

SUBMITTER: Wei L 

PROVIDER: S-EPMC3583134 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature