Excessive folate synthesis limits lifespan in the C. elegans: E. coli aging model.

ABSTRACT:

Background

Gut microbes influence animal health and thus, are potential targets for interventions that slow aging. Live E. coli provides the nematode worm Caenorhabditis elegans with vital micronutrients, such as folates that cannot be synthesized by animals. However, the microbe also limits C. elegans lifespan. Understanding these interactions may shed light on how intestinal microbes influence mammalian aging.

Results

Serendipitously, we isolated an E. coli mutant that slows C. elegans aging. We identified the disrupted gene to be aroD, which is required to synthesize aromatic compounds in the microbe. Adding back aromatic compounds to the media revealed that the increased C. elegans lifespan was caused by decreased availability of para-aminobenzoic acid, a precursor to fo

SUBMITTER: Virk B 

PROVIDER: S-EPMC3583181 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature