Spatial morphological and molecular differences within solid tumors may contribute to the failure of vascular disruptive agent treatments.

ABSTRACT:

Background

Treatment of solid tumors with vascular disrupting agent OXi4503 results in over 90% tumor destruction. However, a thin rim of viable cells persists in the tumor periphery following treatment, contributing to subsequent recurrence. This study investigates inherent differences in the microenvironment of the tumor periphery that contribute to treatment resistance.

Methods

Using a murine colorectal liver metastases model, spatial morphological and molecular differences within the periphery and the center of the tumor that may account for differences in resistance to OXi4503 treatment were investigated. H&E staining and immunostaining were used to examine vessel maturity and stability, hypoxia and HIF1α levels, accumulation of immune cells, expression of proangiogenic

SUBMITTER: Nguyen L 

PROVIDER: S-EPMC3583184 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature