Genetic signatures shared in embryonic liver development and liver cancer define prognostically relevant subgroups in HCC.

ABSTRACT: Multiple activations of individual genes during embryonic liver and HCC development have repeatedly prompted speculations about conserved embryonic signatures driving cancer development. Recently, the emerging discussion on cancer stem cells and the appreciation that generally tumors may develop from progenitor cells of diverse stages of cellular differentiation has shed increasing light on the overlapping genetic signatures between embryonic liver development and HCC. However there is still a lack of systematic studies investigating this area. We therefore performed a comprehensive analysis of differentially regulated genetic signaling pathways in embryonic and liver cancer development and investigated their biological relevance.Genetic signaling pathways were investigated on several publ

SUBMITTER: Becker D 

PROVIDER: S-EPMC3583209 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature