Increased expression of macrophage colony-stimulating factor and its receptor in patients with endometriosis.

ABSTRACT:

Objective

To investigate the expression and regulation of colony-stimulating factor 1 (CSF-1) and its receptor, C-FMS, in endometriosis.

Design

In vivo and vitro study.

Setting

University-based academic medical center.

Patient(s)

Reproductive-age women undergoing surgery for benign conditions.

Intervention(s)

Peritoneal and endometrial tissue samples were obtained.

Main outcome measure(s)

CSF-1 and C-FMS expression.

Result(s)

Significantly higher CSF-1 levels were found in peritoneal fluid of patients with endometriosis compared with control subjects. Ectopic endometriotic tissue had 3.5-fold and 1.7-fold increases in CSF-1 and C-FMS expression, respectively, compared with eutopic tissue. Coculture of endometrial cells from either establish

SUBMITTER: Budrys NM 

PROVIDER: S-EPMC3583230 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature