Dendritic cells and alveolar macrophages mediate IL-13-induced airway inflammation and chemokine production.

ABSTRACT:

Background

IL-13 in the airway induces pathologies that are highly characteristic of asthma, including mucus metaplasia, airway hyperreactivity (AHR), and airway inflammation. As such, it is important to identify the IL-13-responding cell types that mediate each of the above pathologies. For example, IL-13's effects on epithelium contribute to mucus metaplasia and AHR. IL-13's effects on smooth muscle also contribute to AHR. However, it has been difficult to identify the cell types that mediate IL-13-induced airway inflammation.

Objective

We sought to determine which cell types mediate IL-13-induced airway inflammation.

Methods

We treated the airways of mice with IL-13 alone or in combination with IFN-γ. We associated the inhibitory effect of IFN-γ on IL-13-induced ai

SUBMITTER: Crapster-Pregont M 

PROVIDER: S-EPMC3583235 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature