DNA methylation in the developing hippocampus and amygdala of anxiety-prone versus risk-taking rats.

ABSTRACT: All organisms exhibit a wide range of emotional behaviors and interact with the environment in different ways. Some individuals may be more quiet and shy whereas others are more outgoing and adventurous. These temperamental and personality differences can predispose individuals to certain psychopathologies which may be influenced by genetic vulnerability and/or early life experiences. Rodent models can be used to recapitulate emotional reactivity differences, and these models can, in turn, be used to examine potential neurobiological underpinnings of these traits. The present study utilizes two strains of rats that were selectively bred for differences in novelty seeking. High Novelty-Responding (bHR) rats are very active in response to novelty, exhibit exaggerated risk-taking, aggression,

SUBMITTER: Simmons RK 

PROVIDER: S-EPMC3583346 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature