Mitochondrial and Y-chromosomal profile of the Kazakh population from East Kazakhstan.

ABSTRACT:

Aim

To study the genetic relationship of Kazakhs from East Kazakhstan to other Eurasian populations by examining paternal and maternal DNA lineages.

Methods

Whole blood samples were collected in 2010 from 160 unrelated healthy Kazakhs residing in East Kazakhstan. Genomic DNA was extracted with Wizard genomic DNA Purification Kit. Nucleotide sequence of hypervariable segment I of mitochondrial DNA (mtDNA) was determined and analyzed. Seventeen Y-short tandem repeat (STR) loci were studied in 67 samples with the AmpFiSTR Y-filer PCR Amplification Kit. In addition, mtDNA data for 2701 individuals and Y-STR data for 677 individuals were retrieved from the literature for comparison.

Results

There was a high degree of genetic differentiation on the level of mitochondrial DN

SUBMITTER: Tarlykov PV 

PROVIDER: S-EPMC3583390 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature