Neural temporal dynamics of stress in comorbid major depressive disorder and social anxiety disorder.

ABSTRACT:

Background

Despite advances in neurobiological research on Major Depressive Disorder and Social Anxiety Disorder, little is known about the neural functioning of individuals with comorbid depression/social anxiety. We examined the timing of neural responses to social stress in individuals with major depression and/or social anxiety. We hypothesized that having social anxiety would be associated with earlier responses to stress, having major depression would be associated with sustained responses to stress, and that comorbid participants would exhibit both of these response patterns.

Methods

Participants were females diagnosed with pure depression (n = 12), pure social anxiety (n = 16), comorbid depression/social anxiety (n = 17), or as never having had any Axis-I disorder (c

SUBMITTER: Waugh CE 

PROVIDER: S-EPMC3583464 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature