Hyperthermia reduces migration of osteosarcoma by suppression of autocrine motility factor.

ABSTRACT: Autocrine motility factor (AMF) plays an important role in the development of metastasis by regulating tumor cell motility. The expression of AMF is associated with metastasis in malignant musculoskeletal tumors including osteosarcoma. Recent studies indicated that hyperthermia contributes to the improvement of the prognosis of patients with soft tissue sarcomas; however, few reports have evaluated the impact of hyperthermia on tumor cell motility, which is an important factor of metastasis. The purpose of this study was to evaluate the effect of hyperthermia with or without heat shock protein (HSP) inhibitors on the motility and AMF expression in an osteosarcoma cell line. Hyperthermia was carr

SUBMITTER: Nakajima K 

PROVIDER: S-EPMC3583516 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature