Genetic and epigenetic alterations of steroidogenic factor‑1 in ovarian tumors.

ABSTRACT: Steroidogenic factor-1 (SF‑1), the product of the NR5A1 gene, is an essential transcription factor that is known to regulate steroidogenesis in ovarian epithelia, including the synthesis of progesterone, a suppressor of ovarian cancer. Expression of the SF‑1 protein, a potential ovarian tumor suppressor, has been demonstrated in normal OSE cells, but is lost in most ovarian tumors and ovarian tumor cell lines. We examined loss of heterozygosity (LOH) and promoter methylation as potential mechanisms that may explain the loss of SF‑1 protein in ovarian tumor tissues. Genotyping of three NR5A1 SNPs in matched tumor/normal tissues identified LOH in 16/36 (44%) of the ovarian tumors successfully anal

SUBMITTER: Miller S 

PROVIDER: S-EPMC3583749 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature